Extensive multi-year field trials conducted by CIMMYT in Mexico played a pivotal role in validating the efficacy of the Trehalose 6-phosphate (T6P) spray treatment, confirming its potential to boost wheat yields by up to 12%. Despite challenges posed by fluctuating rainfall—an increasingly common constraint under climate change—CIMMYT’s trial plots consistently outperformed untreated controls across four consecutive crop cycles. These results underscore CIMMYT’s leadership in translating laboratory innovations into resilient, field-ready solutions that enhance food security while advancing sustainable agrifood systems in diverse agroecological conditions.

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