Zinc deficiency affects one third of the global population; vitamin A deficiency is a prevalent public health issue in many parts of sub-Saharan Africa and South Asia. This includes countries like Nepal, where alarming rates of micronutrient deficiency contribute to a host of health problems across different age groups, such as stunting, weakened immune systems, and increased maternal and child mortality.
In the absence of affordable options for dietary diversification, food fortification, or nutrient supplementation, crop biofortification remains one of the most sustainable solutions to reducing micronutrient deficiency in the developing world.
After a 2016 national micronutrient status survey highlighted the prevalence of zinc and vitamin A deficiency among rural communities in Nepal’s mountainous western provinces, a team of researchers from the Nepal Agricultural Research Council and the International Maize and Wheat Improvement Center (CIMMYT) proposed a study to assess the yield performance of zinc and provitamin A enriched maize varieties.
Focusing on the river basin area of Karnali Province — where maize is the staple food crop for most people – they conducted two different field trials using an alpha lattice design to identify zinc and provitamin A biofortified maize genotypes consistent and competitive in performance over the contrasting seasons of February to July and August to February.
The study, recently published in Plants, compared the performance of newly introduced maize genotypes with local varieties, focusing on overall agro-morphology, yield, and micronutrient content. In addition to recording higher levels of kernel zinc and total carotenoid, it found that several of the provitamin A and zinc biofortified genotypes exhibited greater yield consistency across different environments compared to the widely grown normal maize varieties.
The results suggest that these genotypes could be effective tools in combatting micronutrient deficiency in the area, thus reducing hidden hunger, as well as enhancing feed nutrient value for the poultry sector, where micronutrient rich maize is highly desired.
“One in three children under the age of five in Nepal and half of the children in the study area are undernourished. Introduction and dissemination of biofortified maize seeds and varieties will help to mitigate the intricate web of food and nutritional insecurity, especially among women and children,” said AbduRahman Beshir, CIMMYT’s seed systems specialist for Asia and the co-author of the publication. Strengthening such products development initiatives and enhancing quality seed delivery pathways will foster sustainable production and value chains of biofortified crops, added Beshir.
Cover photo: Farm worker Bharat Saud gathers maize as it comes out of a shelling machine powered by 4WT in Rambasti, Kanchanpur, Nepal. (Photo: Peter Lowe/CIMMYT)
Scientists at CIMMYT expect to sharply ramp up new wheat varieties enriched with zinc that can boost the essential mineral for millions of poor people with deficient diets, the institute’s head told Reuters.
Wheat fields at Toluca station, Mexico. (Photo: Fernando Delgado/CIMMYT)
On December 11, 2020, the Nepal Agricultural Research Council (NARC) announced the release of six new wheat varieties for multiplication and distribution to the country’s wheat farmers, offering increased production for Nepal’s nearly one million wheat farmers and boosted nutrition for its 28 million wheat consumers.
The varieties, which are derived from materials developed by the International Maize and Wheat Improvement Center (CIMMYT), include five bred for elevated levels of the crucial micronutrient zinc, and Borlaug 100, a variety well known for being high yielding, drought- and heat-resilient, and resistant to wheat blast, as well as high in zinc.
“Releasing six varieties in one attempt is historic news for Nepal,” said CIMMYT Asia Regional Representative and Principal Scientist Arun Joshi.
“It is an especially impressive achievement by the NARC breeders and technicians during a time of COVID-related challenges and restrictions,” said NARC Executive Director Deepak Bhandari.
“This was a joint effort by many scientists in our team who played a critical role in generating proper data, and making a strong case for these varieties to the release committee, ” said Roshan Basnet, head of the National Wheat Research Program based in Bhairahawa, Nepal, who was instrumental in releasing three of the varieties, including Borlaug 2020.
“We are very glad that our hard work has paid off for our country’s farmers,” said Dhruba Thapa, chief and wheat breeder at NARC’s National Plant Breeding and Genetics Research Centre.
Nepal produces 1.96 million tons of wheat on more than 750,000 hectares, but its wheat farmers are mainly smallholders with less than 1-hectare holdings and limited access to inputs or mechanization. In addition, most of the popular wheat varieties grown in the country have become susceptible to new strains of wheat rust diseases.
The new varieties — Zinc Gahun 1, Zinc Gahun 2, Bheri-Ganga, Himganga, Khumal-Shakti and Borlaug 2020 — were bred and tested using a “fast-track” approach, with CIMMYT and NARC scientists moving material from trials in CIMMYT’s research station in Mexico to multiple locations in Nepal and other Target Population of Environments (TPEs) for testing.
“Thanks to a big effort from Arun Joshi and our NARC partners we were able to collect important data in first year, reducing the time it takes to release new varieties,” said CIMMYT Head of Wheat Improvement Ravi Singh.
The varieties are tailored for conditions in a range of wheat growing regions in the country — from the hotter lowland, or Terai, regions to the irrigated as well as dryer mid- and high-elevation areas — and for stresses including wheat rust diseases and wheat blast. The five high-zinc, biofortified varieties were developed through conventional crop breeding by crossing modern high yielding wheats with high zinc progenitors such as landraces, spelt wheat and emmer wheat.
“Zinc deficiency is a serious problem in Nepal, with 21% of children found to be zinc deficient in 2016,” explained said CIMMYT Senior Scientist and wheat breeder Velu Govindan, who specializes in breeding biofortified varieties. “Biofortification of staple crops such as wheat is a proven method to help reverse and prevent this deficiency, especially for those without access to a more diverse diet.”
Borlaug 2020 is equivalent to Borlaug 100, a highly prized variety released in 2014 in adbMexico to commemorate the centennial year of Nobel Peace laureate Norman E. Borlaug. Coincidently, its release in Nepal coincides with the 50th anniversary of Borlaug’s Nobel Peace Prize.
NARC staff have already begun the process of seed multiplication and conducting participatory varietal selection trials with farmers, so very soon farmers throughout the country will benefit from these seeds.
“The number of new varieties and record release time is amazing,” said Joshi. “We now have varieties that will help Nepal’s farmers well into the future.”
CIMMYT breeding of biofortified varieties was funded by HarvestPlus. Variety release and seed multiplication activities in Nepal were supported by NARC and the Asian Development Bank (ADB) through collaboration with ADB Natural Resources Principal & Agriculture Specialist Michiko Katagami. This NARC-ADB-CIMMYT collaboration was prompted by World Food Prize winner and former HarvestPlus CEO Howarth Bouis, and provided crucial support that enabled the release in a record time.
The International Maize and Wheat Improvement Center (CIMMYT) is the global leader in publicly-funded maize and wheat research and related farming systems. Headquartered near Mexico City, CIMMYT works with hundreds of partners throughout the developing world to sustainably increase the productivity of maize and wheat cropping systems, thus improving global food security and reducing poverty. CIMMYT is a member of the CGIAR System and leads the CGIAR Research Programs on Maize and Wheat and the Excellence in Breeding Platform. The Center receives support from national governments, foundations, development banks and other public and private agencies. For more information, visit staging.cimmyt.org.
ABOUT NARC:
Nepal Agricultural Research Council (NARC) was established in 1991 as an autonomous organization under Nepal Agricultural Research Council Act – 1991 to conduct agricultural research in the country to uplift the economic level of Nepalese people.
ABOUT ADB:
The Asian Development Bank (ADB) is committed to achieving a prosperous, inclusive, resilient, and sustainable Asia and the Pacific, while sustaining its efforts to eradicate extreme poverty. It assists its members and partners by providing loans, technical assistance, grants, and equity investments to promote social and economic development.
The public sector plays a vital catalytic role, through enabling policies and programs, in ensuring that biofortified crops like iron pearl millet, zinc wheat, and zinc rice reach the most vulnerable populations to address the problem of ‘hidden hunger’.
Velu Govindan will always remember his father telling him not to waste his food. “He used to say that rice and wheat are very expensive commodities, which most people could only afford to eat once a week during his youth,” recalls the wheat breeder, who works at the International Maize and Wheat Improvement Center (CIMMYT).
As in many parts of the world, the Green Revolution had a radical impact on agricultural production and diets in southern India, where Govindan’s father grew up, and by the late 1960s all farmers in the area had heard of “the scientist” from the USA. “Borlaug’s influence in India is so great because those new high-yielding varieties fed millions of people — including me.”
But feeding millions was only half the battle.
Today, at least two billion people around the world currently suffer from micronutrient deficiency, characterized by iron-deficiency anemia, lack of vitamin A and zinc deficiency.
Govindan works in collaboration with HarvestPlus to improve nutritional quality in cereals in addition to core traits like yield potential, disease resistance and climate tolerance. His area of focus is South Asia, where wheat is an important staple and many smallholder farmers don’t have access to a diversified diet including fruit, vegetables or animal products which are high in micronutrients like iron and zinc.
“It’s important that people not only have access to food, but also have a healthy diet,” says Govindan. “The idea is to improve major staples like rice, maize and wheat so that people who consume these biofortified varieties get extra benefits, satisfying their daily dietary needs as well as combatting hidden hunger.”
The challenge, he explains, is that breeding for nutritional quality is often done at the expense of yield. But varieties need high yield potential to be successful on the market because farmers in developing countries will not get a premium price simply for having a high micronutrient content in their grain.
Fast evolving wheat diseases are another issue to contend with. “If you release a disease-resistant variety today, in as little as three or four years’ time it will already be susceptible because rust strains keep mutating. It’s a continuous battle, but that’s plant breeding.”
Velu Govindan speaks at International Wheat Conference in 2015. (Photo: Julie Mollins/CIMMYT)
Mainstreaming zinc
When it comes to improvement, breeding is only the first part of the process, Govindan explains. “We can do a good job here in the lab, but if our varieties are not being taken up by farmers it’s no use.”
Govindan and his team work in collaboration with a number of public and private sector organizations to promote new varieties, partnering with national agricultural research systems and advanced research institutes to reach farmers in India, Nepal and Pakistan. As a result, additional high-zinc varieties have been successfully marketed and distributed across South Asia, as well as new biofortified lines which are currently being tested in sub-Saharan Africa for potential release and cultivation by farmers.
Their efforts paid off with the development and release of more than half dozen competitive high-zinc varieties including Zinc-Shakthi, whose grain holds 40% more zinc than conventional varieties and yields well, has good resistance to rust diseases, and matures a week earlier than other popular varieties, allowing farmers to increase their cropping intensity. To date, these biofortified high-zinc wheat varieties have reached nearly a million households in target regions of South Asia and are expected to spread more widely in coming years.
The next step will be to support the mainstreaming of zinc, so that it becomes an integral part of breeding programs as opposed to an optional addition. “Hopefully in ten years’ time, most of the wheat we eat will have those extra benefits.”
There may be a long way to go, but Govindan remains optimistic about the task ahead.
Velu Govindan examines wheat in the field.
Born into a farming family, he has fond memories of a childhood spent helping his father in the fields, with afternoons and school holidays dedicated to growing rice, cotton and a number of other crops on the family plot.
The region has undergone significant changes since then, and farmers now contend with both rising temperatures and unpredictable rainfall. It was a motivation to help poor farmers adapt to climate change and improve food production that led Govindan into plant breeding.
He has spent nearly ten years working on CIMMYT’s Spring Wheat Program and still feels honored to be part of a program with such a significant legacy. “Norman Borlaug, Sanjay Rajaram and my supervisor Ravi Singh — these people are legendary,” he explains. “So luckily we’re not starting from scratch. These people made life easy, and we just need to keep moving towards achieving continuous genetic gains for improved food and nutrition security.”
Around 10 years ago, CIMMYT began work on developing wheat with higher zinc and iron, under an initiative called HarvestPlus. CIMMYT has released eleven varieties of zinc wheat in India, which are also high-yielding and disease-resistant. Read more here.
In 2016, the emergence of wheat blast, a devastating seed- and wind-borne pathogen, threatened an already precarious food security situation in Bangladesh and South Asia.
In a bid to limit the disease’s impact in the region, the Bangladesh Agricultural Research Institute (BARI) collaborated with the International Maize and Wheat Improvement Center (CIMMYT) and researchers from nearly a dozen institutions worldwide to quickly develop a long-term, sustainable solution.
The result is BARI Gom 33, a new blast-resistant, high-yielding, zinc-fortified wheat variety, which Bangladesh’s national seed board approved for dissemination in 2017. In the 2017-18 season, the Bangladesh Wheat Research Council provided seed for multiplication and the country’s Department of Agricultural Extension established on-farm demonstrations in blast prone districts.
However, the process of providing improved seed for all farmers can be a long one. In a normal release scenario, it can take up to five years for a new wheat variety to reach those who need it, as nucleus and breeder seeds are produced, multiplied and certified before being disseminated by extension agencies. Given the severity of the threat to farmer productivity and the economic and nutritional benefits of the seed, scientists at CIMMYT argue that additional funding should be secured to expedite this process.
According a new study on the economic benefits of BARI Gom 33, 58 percent of Bangladesh’s wheat growing areas are vulnerable to wheat blast. The rapid dissemination of seed can help resource-poor farmers better cope with emerging threats and changing agro-climatic conditions, and would play a significant role in combatting malnutrition through its increased zinc content. It could also have a positive effect on neighboring countries such as India, which is alarmingly vulnerable to wheat blast.
“Our simulation exercise shows that the benefits of disseminating BARI Gom 33 far exceed the seed multiplication and dissemination costs, which are estimated at around $800 per hectare,” explains Khondoker Mottaleb, CIMMYT socioeconomist and lead author of the study. Even in areas unaffected by wheat blast, scaling out BARI Gom 33 could generate a net gain of $8 million for farmers due to its 5 percent higher average yield than other available varieties. These benefits would nearly double in the case of an outbreak in blast-affected or blast-vulnerable districts.
More than 50 percent of Bangladesh’s wheat growing areas are vulnerable to wheat blast. (Source: Mottaleb et al.)
Based on these findings, the authors urge international development organizations and donor agencies to continue their support for BARI Gom 33, particularly for government efforts to promote the blast-resistant variety. The minimum seed requirement to begin the adoption and diffusion process in the 2019-20 wheat season will be 160 metric tons, which will require an initial investment of nearly $1 million for seed multiplication.
This study was supported by the CGIAR Research Program on wheat agri-food systems (CRP WHEAT), the Australian Centre for International Agricultural Research (ACIAR), the CGIAR Research Program on Agriculture for Nutrition and Health (CRP-A4NH), and the HarvestPlus challenge program (partly funded by the Bill and Melinda Gates Foundation).
TEXCOCO, Mexico (CIMMYT) — More nutritious crop varieties developed and spread through a unique global science partnership are offering enhanced nutrition for hundreds of millions of people whose diets depend heavily on staple crops such as maize and wheat, according to a new studyin the science journal Cereal Foods World.
From work begun in the late 1990s and supported by numerous national research organizations and scaling partners, more than 60 maize and wheat varieties whose grain features enhanced levels of zinc or provitamin A have been released to farmers and consumers in 19 countries of Africa, Asia, and Latin America over the last 7 years. All were developed using conventional cross-breeding.
Farmer and consumer interest has grown for some 60 maize and wheat varieties whose grain features enhanced levels of the essential micronutrients zinc and provitamin A, developed and promoted through collaborations of CIMMYT, HarvestPlus, and partners in 19 countries (Map: Sam Storr/CIMMYT).
“The varieties are spreading among smallholder farmers and households in areas where diets often lack these essential micronutrients, because people cannot afford diverse foods and depend heavily on dishes made from staple crops,” said Natalia Palacios, maize nutrition quality specialist at the International Maize and Wheat Improvement Center (CIMMYT) and co-author of the study.
More than 2 billion people worldwide suffer from “hidden hunger,” wherein they fail to obtain enough of such micronutrients from the foods they eat and suffer serious ailments including poor vision, vomiting, and diarrhea, especially in children, according to Wolfgang Pfeiffer, co-author of the study and head of research, development, delivery, and commercialization of biofortified crops at the CGIAR program known as “HarvestPlus.”
“Biofortification — the development of micronutrient-dense staple crops using traditional breeding and modern biotechnology — is a promising approach to improve nutrition, as part of an integrated, food systems strategy,” said Pfeiffer, noting that HarvestPlus, CIMMYT, and the International Institute of Tropical Agriculture (IITA) are catalyzing the creation and global spread of biofortified maize and wheat.
“Eating provitamin A maize has been shown to be as effective as taking Vitamin A supplements,” he explained, “and a 2018 study in India found that using zinc-biofortified wheat to prepare traditional foods can significantly improve children’s health.”
Six biofortified wheat varieties released in India and Pakistan feature grain with 6–12 parts per million more zinc than is found traditional wheat, as well as drought tolerance and resistance to locally important wheat diseases, said Velu Govindan, a breeder who leads CIMMYT’s work on biofortified wheat and co-authored the study.
“Through dozens of public–private partnerships and farmer participatory trials, we’re testing and promoting high-zinc wheat varieties in Afghanistan, Ethiopia, Nepal, Rwanda, and Zimbabwe,” Govindan said. “CIMMYT is also seeking funding to make high-zinc grain a core trait in all its breeding lines.”
Pfeiffer said that partners in this effort are promoting the full integration of biofortified maize and wheat varieties into research, policy, and food value chains. “Communications and raising awareness about biofortified crops are key to our work.”
For more information or interviews, contact:
Mike Listman Communications Consultant
International Maize and Wheat Improvement Center (CIMMYT)
m.listman@cgiar.org, +52 (1595) 957 3490
On World Food Day, October 16, the International Maize and Wheat Improvement Center (CIMMYT) joins the Food and Agriculture Organization of the United Nations and partners around the world in their call to realize Sustainable Development Goal 2: Zero Hunger by 2030. Learn how CIMMYT, HarvestPlus and Semilla Nueva are working together to use biofortified zinc-enriched maize to reduce malnutrition in Guatemala, an important component of Goal 2.
Over 46 percent of children under five in Guatemala suffer from chronic malnutrition. More than 40 percent of the country’s rural population is deficient in zinc, an essential micronutrient that plays a crucial role in pre-natal and post-natal development and is key to maintaining a healthy immune system. CIMMYT, HarvestPlus and Semilla Nueva are working together to change this, through the development and deployment of the world’s first biofortified zinc-enriched maize.
“In Latin America, Guatemala is among the top 3 countries with the highest rates of zinc and iron deficiencies, and it is characterized by a high production and consumption of staple foods such as maize and beans. This made Guatemala, along with Haiti, the top prioritized countries for biofortification in the region, according to the Biofortification Priority Index (BPI) for Latin America,” said Salomón Pérez, the HarvestPlus country coordinator for Guatemala. HarvestPlus developed the BPI in 2013 to select the countries, crops and micronutrients in which to focus their efforts in Latin America. The BPI combines three sub-indexes: production, consumption and micronutrient deficiency level. “As maize is a staple food in Guatemala, with high levels of consumption and production, the development of biofortified maize with enhanced zinc was prioritized for the country,” he said.
Biofortified maize is a unique and efficient way of improving nutrition. As the nutrients occur naturally in the plant, consumers do not have to make any behavioral changes to get results. Rather than having to import supplements or fortify food, seeds and crops are sourced within the country, which makes this option more sustainable and accessible even in remote rural areas. It tastes the same as non-biofortified maize varieties and requires no special preparation methods. This made biofortification the obvious choice for improving zinc deficiency in Guatemala, and CIMMYT the obvious partner.
“CIMMYT has over 50 years of experience in tropical maize breeding for different traits,” said Félix San Vicente, one of the CIMMYT maize breeders leading the project. “Throughout our history we have developed elite materials with important agronomic and nutritional traits, such as Quality Protein Maize (QPM).”
The long lineage of zinc maize
Developed by CIMMYT scientists Evangelina Villegas and Surinder Vasal, QPM has enhanced levels of lysine and tryptophan, essential amino acids, which can help reduce malnutrition in children. Villegas and Vasal would later go on to win the World Food Prize in 2000 for this groundbreaking work, and genetic variation found in QPM would serve as the baseline for developing zinc-enriched maize.
A maize plot of the Fortaleza F3 variety in Guatemala. Photo: Sarah Caroline Mueller.
After years of breeding work and research, the world’s first biofortified zinc maize hybrid, ICTA HB-18, was released in Guatemala in May 2018. It was developed by CIMMYT, the CGIAR Research Programs on Maize (MAIZE) and Agriculture for Nutrition and Health (A4NH), and Guatemala’s Institute for Agricultural Science and Technology (ICTA) with support from HarvestPlus. Commercialized by Semilla Nueva under the name Fortaleza F3, the biofortified zinc maize hybrid contains 6-12ppm more zinc and 2.5 times more quality protein compared to conventional maize varieties. An open pollinated variety, ICTA B-15, was also released.
Just 100 grams of tortilla made of either of these varieties can provide 2.5 milligrams of zinc, 50 percent of the daily recommended intake for children, making zinc-enriched biofortified maize an excellent tool in the fight against malnutrition and hidden hunger.
As CIMMYT is a breeding organization, it depends on national partners to get seeds to the farmers. That is where Semilla Nueva comes in. This non-profit social enterprise is working to get high yielding biofortified seeds to farmers in Guatemala.
Rómulo González’s daughter holds a corncob. Photo: Sarah Caroline Mueller.
The last mile
“We need to be able to impact farmers with our improved germplasm,” said San Vicente. “Semilla Nueva takes us to the last mile, to the farmers, which alone we could not do, so that our breeding work can achieve impact in farmers’ fields and lives.”
Semilla Nueva targets commercial farmers in Guatemala, as they are the main source of maize consumed in the country. Typically, a quarter of their harvest is consumed at home and surplus is sold in local markets, meaning that the zinc maize not only provides increased income to farmers, but also improves nutrition in their families, communities and country at large.
“CIMMYT, along with partners like HarvestPlus, have provided the technologies and support to allow us to come up with new ways to improve farmers’ lives. Tapping into decades of research from qualified scientists is the only way that an organization of our size can have hope of making an impact in the lives of millions of farmers. That’s what makes the partnership so incredible,” said Curt Bowen, executive director and cofounder of Semilla Nueva. “We provide the innovative way to get technologies to farmers through our social enterprise model. CIMMYT and HarvestPlus come up with the technologies that we never could have come up with on our own. Together, we help thousands of families make huge changes in their lives and take on malnutrition, which is one of the world’s biggest challenges to ending global poverty.”
Semilla Nueva plans to produce 5,000 bags of Fortaleza F3 next year, which will represent 5 percent of the Guatemalan hybrid seed market.
Farmer Rómulo González on his maize plot.Photo: Sarah Caroline Mueller.
“Farmers have responded very positively to Fortaleza F3. They are convinced of its performance, especially during the dry season,” said Angela Bastidas, senior operations director at Semilla Nueva. “The way we approach farmers is not different than other seed companies; through farm visits, meetings, or field days. We are not reinventing the wheel. The difference with us has been offering farmers exactly what they need in terms of maize performance and price. Additionally, they find that our maize produces soft tortillas that taste better!” she explained.
In the end, the results speak for themselves. Fortaleza F3 increases yields by 13 percent and profits by $164 per bag compared to other mid-priced seeds, which goes a long way in improving farming families’ livelihoods, food security and nutrition.
“With Fortaleza F3, I pay less for the seed compared to other mid-priced competitors that I used to plant. F3 also yields more, giving me a greater profit,” said Rómulo González, a farmer from the southern coast of Guatemala. “With the extra income I’ve gotten since switching to F3, I’ve been paying for my daughter to go to school. Fortaleza F3 not only gave me a good harvest, but also the ability to support my daughter’s education.”
The reported work by wheat scientists paves the way for expanded use of wild grass species, such as Aegilops tauschii (also known as goat grass; pictured here) as sources of new genes for higher grain zinc in wheat. (Photo: CIMMYT)
An international team of scientists applied genome-wide association analysis for the first time to study the genetics that underlie grain zinc concentrations in wheat, according to a report published in Nature Scientific Reports on September 10.
Analyzing zinc concentrations in the grain of 330 bread wheat lines across diverse environments in India and Mexico, the researchers uncovered 39 new molecular markers associated with the trait, as well as two wheat genome segments that carry important genes for zinc uptake, translocation, and storage in wheat.
The findings promise greatly to ease development of wheat varieties with enhanced levels of zinc, a critical micronutrient lacking in the diets of many poor who depend on wheat-based food, according to Velu Govindan, wheat breeder at the International Maize and Wheat Improvement Center (CIMMYT) and first author of the new report.
“A collaboration among research centers in India, Australia, the USA and Mexico, this work will expedite breeding for higher zinc through use of ‘hotspot’ genome regions and molecular markers,” said Govindan. “It also advances efforts to make selection for grain zinc a standard feature of CIMMYT wheat breeding. Because varieties derived from CIMMYT breeding are grown on nearly half the world’s wheat lands, ‘mainstreaming’ high zinc in breeding programs could improve the micronutrient nutrition of millions.”
More than 17 percent of humans, largely across Africa and Asia, lack zinc in their diets, a factor responsible for the deaths of more than 400,000 young children each year.
Often used in human disease research, the genome-wide association approach was applied in this study to zero in on genome segments — known as quantitative trait loci (QTLs) — that carry genes of interest for wheat grain zinc content, according to Govindan.
“The advantages of the genome-wide association method over traditional QTL mapping include better coverage of alleles and the ability to include landraces, elite cultivars, and advanced breeding lines in the analysis,” he explained. “Our study fully opens the door for the expanded use of wheat progenitor species as sources of alleles for high grain zinc, and the outcomes helped us to identify other candidate genes from wheat, barley, Brachypodium grasses and rice.”
Farmers in South Asia are growing six zinc-enhanced wheat varieties developed using CIMMYT breeding lines and released in recent years, according to Ravi Singh, head of the CIMMYT Bread Wheat Improvement Program.
Financial support for this study was provided by HarvestPlus (www.HarvestPlus.org), a global alliance of agriculture and nutrition research institutions working to increase the micronutrient density of staple food crops through biofortification. The views expressed do not necessarily reflect those of HarvestPlus. It was also supported by CGIAR Funders, through the Research Program on Wheat and the Research Program on Agriculture for Nutrition and Health. Research partners in India and Pakistan greatly contributed to this study by conducting high-quality field trials.
Left to right: Miguel Lengua, director general of Maxi Semillas S.A.S; Bram Govaerts, Latin America regional director at CIMMYT; Martin Kropff, CIMMYT director general; Howdy Bouis, interim HarvestPlus CEO; and Felix San Vicente, CIMMYT maize breeder; at the launch of new biofortified zinc maize. (Photo: Jennifer Johnson/CIMMYT)
Cali, Colombia (CIMMYT) — A new zinc-enriched maize variety was released in Colombia on February 23 to help combat malnutrition in South America.
Zinc is an essential mineral that plays an important role in human development but is not naturally produced by humans. Zinc deficiency can lead to impaired growth and development, respiratory infections, diarrheal disease and a general weakening of the immune system. In Colombia, an average of 22 percent of the population is affected by zinc deficiency. However, in certain regions, such as the pacific coast and Amazonia, up to 65 percent of the population is deficient in zinc.
CIMMYT Director General Martin Kropff speaks at the launch of zinc-enriched maize. (Photo: Jennifer Johnson/CIMMYT)
“The support that CIMMYT and CIAT have received from HarvestPlus has been fundamental in allowing our researchers to develop crops with enhanced vitamin and mineral content,” said Martin Kropff, CIMMYT director general. “The improved maize that we present today is an important example of the impact we can have when we work together in partnership.”
The minimum daily requirement for zinc is 15mg, but not everyone has access to foods with naturally occurring quantities of zinc, which makes this zinc-enriched maize variety a boost for nutrition in a region where maize is a staple food.
BIO-MZN01 contains 36 percent more zinc on average than other maize varieties, meaning that arepas (a common maize-based Colombian dish) made of this new variety offer consumers up to five times more zinc than those made with traditional varieties. Additionally, BIO-MZN01 can yield up to 6 to 8 tons per hectare(t/ha), nearly double the national average in Colombia of 3.7 t/ha and is tolerant to several maize diseases that are common in the region, including rust, turcicum leaf blight, and gray leaf spot. Another advantage is it can be grown between 0 and 1400 meters above sea level during both cropping seasons in the country.
The official launch of BIO-MZN01 was held at CIAT in Palmira, Colombia, and was attended by local farmers, seed companies, and government officials as well as CIMMYT, HarvestPlus and CIAT staff. As part of the launch, visitors and staff were invited into the field to see the variety firsthand and learn more about its properties and the history of its development.
New zinc-biofortified maize variety BIO-MZn01. (Photo: CIMMYT)
“The conservation and utilization of genetic diversity have been crucial for the development of this new biofortified variety, as well as other CIMMYT varieties with improved nutrition or resistance to climate change,” said Natalia Palacios, maize nutritional quality specialist at CIMMYT. “This has been an inter-institutional and interdisciplinary effort at all levels of the maize value chain.”
Other products of the CIMMYT/HarvestPlus partnership include zinc-enriched wheat and biofortified provitamin A maize, which helps to prevent blindness in children.
“We have been working with CIMMYT since HarvestPlus began,” said Marilia Nutti, the regional director for Latin America and the Caribbean at HarvestPlus. “The greatest advantage of working with CIMMYT is their quality research—CIMMYT has all of the knowledge of maize and wheat, and maize is a big part of the diet in Latin America. Meanwhile, HarvestPlus and CIAT already had the partnerships on the ground in Colombia to ensure that this improved zinc maize could get to farmers and consumers. This has truly been a win-win partnership to improve nutrition.”
A farmer examines a zinc-enriched maize plant. (Photo: CIMMYT)
The scientific work conducted at CIMMYT, HarvestPlus and CIAT reaches the hands of farmers through local seed companies such as Maxi Semillas S.A.S., a partner of CIMMYT Colombia for the past 40 years that will be commercializing the new variety. “These varieties are the product of an incredibly long and costly investigation that we do not have the resources to conduct ourselves. In turn we work to ensure that the variety can reach the hands of the farmers and consumers that need it most,” said Miguel Lengua, director general of Maxi Semillas S.A.S.
The variety will be sold at a similar price to currently available maize varieties in Colombia, and certified seed will be available beginning in August.
BIO-MZN01 will also form part of a new initiative in Colombia called “Semillas para la Paz,” or Seeds for Peace, which seeks to provide improved seed varieties as an alternative to illicit crops. The program, organized by the Colombian government and the Colombian Agricultural Research Corporation (CORPOICA), will promote the cultivation of nine different crops, including maize and beans. Over 20 tons of this new zinc-enriched maize variety will be produced by Maxi Semillas for this program, along with an iron-enriched biofortified bean variety developed by CIAT with HarvestPlus.
New study flattens claims that gluten and wheat are bad for human health. Photo: CIMMYT archives
FOR IMMEDIATE RELEASE
EL BATAN, Mexico (CIMMYT) – A new, exhaustive review of recent scientific studies on cereal grains and health has shown that gluten- or wheat-free diets are not inherently healthier for the general populace and may actually put individuals at risk of dietary deficiencies.
Based on a recent, special compilation of 12 reports published in the scientific journal Cereal Foods World during 2014-2017, eating whole grains is actually beneficial for brain health and associated with reduced risk of diverse types of cancer, coronary disease, diabetes, hypertension, obesity and overall mortality.
“Clear and solid data show that eating whole-grain wheat products as part of a balanced diet improves health and can help maintain a healthy body weight, apart from the 1 percent of people who suffer from celiac disease and another 2 to 3 percent who are sensitive to wheat,” said Carlos Guzmán, wheat nutrition and quality specialist at the Mexico-based International Maize and Wheat Improvement Center (CIMMYT), which produced the compilation.
Guzmán said wheat and other grains are inexpensive sources of energy that also provide protein, digestible fiber, minerals, vitamins, and other beneficial phytochemicals.
“Among wheat’s greatest benefits, according to the research, is fiber from the bran and other grain parts,” he explained. “Diets in industrialized countries are generally deficient in such fiber, which helps to regulate digestion and promote the growth of beneficial gut bacteria.”
Contributing to humankind’s development for the last 10,000 years, wheat is cultivated on some 220 million hectares (539 million acres) worldwide. The crop accounts for a fifth of the world’s food and is the main source of protein in many developing and developed countries, and second only to rice as a source of calories globally. In the many countries where milling flours are fortified, wheat-based foods provide necessary levels of essential micronutrients such as iron, zinc, folic acid and vitamin A.
Inhabitants in developing and industrialized countries are experiencing higher incidences of diabetes, allergies, inflammatory bowel disorder, and obesity. A profitable industry has developed around gluten- and wheat-free food products, which the popular press has promoted as beneficial for addressing such disorders. But much scientific evidence contradicts popular writings about these food products.
“Much of the anti-grain messaging comes from publications produced by supposed ‘specialists’ who are not nutritionists, and are often built on faulty premises.” according to Julie Miller Jones, Distinguished Scholar and Professor Emerita at St. Catherine University, U.S.A., and a key contributor to the review studies in the compilation.
“Causes of obesity and chronic disease are complex, and it is not only simplistic but erroneous to name a single food group as the cause or the cure for these problems,” Miller Jones explained. “We do know that we consume large portions, too many calories, and too few fruits, vegetables, or whole grains. Instead today’s lifestyles encourage consumption of many high calorie foods and beverages that contain few nutrients. Then the risks of poor diets are often amplified by our sedentary lifestyles.”
CIMMYT scientists are concerned that the negative portrayal of wheat to promote the lucrative gluten-free fad diet industry will discourage low-income families from consuming the grain as part of an affordable and healthy diet, particularly in areas where there are few low-cost alternatives.
Consumer Reports magazine reported in January 2015 that sales of “gluten-free” products soared 63 percent between 2012 and 2015, with almost 4,600 products introduced in 2014 alone. Retail sales of gluten-free foods in the United States were estimated at $12.2 billion in 2014 and by 2020 the market is projected to be valued at $23.9 billion, Statistica reports.
However, wheat biofortified through breeding or fortified during milling with zinc and iron can play a vital role in diets in areas where “hidden hunger” is a concern and where nutritional options are unaffordable or unavailable. About 2 billion people worldwide suffer from hidden hunger, which is characterized by iron-deficiency anemia, vitamin A and zinc deficiency.
The compilation draws on more than 1,500 peer-reviewed studies regarding the dietary and health effects of eating cereals and wheat-based foods.
CIMMYT specialists also worry that misinformation about wheat might affect investments in vital research to sustain wheat production increases of at least 60 percent by 2050, the output required to keep pace with rising population and demand, according to Hans Braun, director of the center’s global wheat program.
“Climate change is already constraining wheat production in regions such as South Asia, where more than 500 million inhabitants eat wheat-based foods,” Braun said. “Worldwide, the crop is threatened by deadly pest and disease strains, water shortages, and depleted soils.”
“As we have seen in 2008, 2011, and just recently in Tunisia and Sudan, grain shortages or price hikes in bread can lead to social unrest,” Braun added. “The international community needs to speed efforts to develop and share high-yielding, climate-resilient, and disease-resistant wheat varieties that also meet humanity’s varied nutritional demands.”
The compilation was produced with special permission from AACC International.
FOR FURTHER INFORMATION OR INTERVIEWS
Mike Listman
Communications officer, CGIAR Research Program on Wheat
tel: +52 (55) 5804 7537
cel: +52 (1595) 114 9743
Email: m.listman@cgiar.org
