Maize, along with wheat and rice, provides around 30% of food calories to more than 4.5 billion people in 94 developing countries. These statistics declare that maize is an important crop to ensure food and nutritional security for poor communities in Africa, Asia and Latin America.
Limited diversification in dietary food and higher per capita maize consumption indicates that a great proportion of the population in developing countries are lacking in essential nutrients like micronutrients and amino acids.
Rigorous efforts by International Maize and Wheat Improvement Center (CIMMYT) maize breeder Surinder K. Vasal and cereal chemist Evangelina Villegas in the early 1980s led to the development of an improved maize kernel with higher yield and vitreous appearance by combining the opaque-2 and genetic modifier systems by using backcrossing and recurrent selection. These efforts led to development of an improved maize known as quality protein maize (QPM).
QPM ensures the nutritional security of maize dependent communities. It is described as nutritionally superior maize with high lysine, tryptophan and leucine contents along with high biological value and high protein intake. QPM also has higher contents of non-zein protein (albumin, globulin and glutelin fractions), which are rich in lysine and tryptophan.
The development of QPM was comprised of a series of efforts across many decades to develop promising varieties. CIMMYT described the term QPM for maize genotypes with improved lysine and tryptophan contents and hard endosperm texture. Now, QPM is referred to maize genotypes with homozygous o2 alleles, increased lysine and tryptophan contents, and without harboring the negative pleiotropic effects of soft endosperm.
In recent years, CIMMYT has developed several QPM varieties across many countries with different genetic backgrounds. However, to fast track the deployment of QPM at scale, it needs a vibrant seed system in place and a viable business model which ensures an active engagement of seed producers, farmers and consumers.
This review article discusses the importance and timeline of various events in QPM development and dissemination, genetic basis and systems, breeding strategies, challenges and potential opportunities for QPM adoption. “We can consider the article as a compendium of QPM where it addresses historical background and scientific breakthroughs which will be useful to researchers, students and others who are looking for a comprehensive information on QPM,” said AbduRahman Beshir, CIMMYT’s senior scientist and maize seed systems specialist for Asia, who co-authored the publication.
The demand for maize for poultry feed in Nepal has increased dramatically over the years. It constitutes about 60% of the poultry feed and is considered as the principal energy source used in poultry diets. About 70% of the total crop required by the feed industry is imported and such dependence on import could jeopardize its sustainability if any political, natural or health related crisis disrupts the supply chain. In addition to maize, the industry also imports synthetic amino acid to meet the requirements of poultry production since the regular maize grain used by the feed industry is deficient in essential amino acids that helps form proteins.
A recent assessment conducted by the International Maize and Wheat Improvement Center (CIMMYT) in Nepal highlights the prospects of using Quality Protein Maize (QPM) to mitigate protein deficiency found in regular maize. The authors suggest that the poultry feed industry can minimize the average feed cost by 1.5% by substituting regular maize with QPM. This would translate to a daily cost-saving of about US$26,000 for the industry. If this cost saving is shared across the value chain actors including farmers for domestic production of QPM and other biofortified maize vis a vis regular maize, then the dependency on imported maize can be significantly reduced.
The article published in the journal of International Food and Agribusiness Marketing, estimated least cost diet formulations for broilers and layers of different age groups, and the potential gains to be garnered by the maize seed and grain value chain actors in Nepal.
According to the study, a ton of feed produced using QPM reduces feed cost by at least US$7.1 for the broilers and by US$4.71 for layers. As a result, Nepal’s poultry feed industry can pay a maximum of 4% price premium with the cost saving for QPM.
“Considering the cost reduction potential QPM brings over regular maize, it can be a win-win situation for the poultry feed sector and maize value chain actors if they are strongly linked and operated in an integrated fashion,” explain the authors.
“By building awareness on the cost benefits, the feed industry exhibited a positive perception during the study period to use QPM for feed. Linking the seed companies with the feed mills is essential to leverage the benefits of the product.”
To promote and expand QPM production in Nepal, the authors also recommend provision of seed and fertilizer subsidies by the Government of Nepal to feed producers and cooperatives ensuring a continuous supply of the product to meet the demand.
The GoN has released two varieties of QPM maize but due to lack of effective seed production, extension and marketing programs, the potential of QPM maize remains unutilized. However, the authors firmly believe that appropriate policy focus on QPM seed production and grain marketing including premium price for QPM growers, can change the scenario where the demand for maize for feed industry can be gradually managed with domestic production.
The International Maize and Wheat Improvement Center (CIMMYT) and Ethiopia’s Ministry of Agriculture held a workshop on March 23, 2019, with the main stakeholders of the agricultural research and seed sectors to discuss how Quality Protein Maize (QPM) production and demand could be expanded, to ensure lasting nutrition benefits for consumers and incomes for farmers.
Maize is the second most cultivated cereal in Ethiopia, with 66% of cereal-farming households cultivating maize on 2.1 million hectares. It is a primary staple food in the major maize-growing areas as well as a source of feed for animals and a raw material for industries. With increasing pressures from climate change and population growth, maize is likely to be key to meeting the challenges of food and income security.
Despite its high productivity, maize grain does not provide balanced protein for human consumption. It is deficient in two essential amino acids, lysine and tryptophan, putting those who consume maize without alternative protein sources at risk of malnutrition and stunted growth and development. Infants and young children are especially at risk. Complementary and alternative sources of protein such as legumes or animal products — meat, eggs and milk – are often inaccessible or unaffordable to the poorest households.
QPM is a type of maize, developed through conventional breeding, that contains nearly twice the amount of tryptophan and lysine compared to common varieties. Research shows that eating QPM can improve quality protein intake among young children and QPM is nutritionally advantageous over conventional maize, especially for families with an undiversified diet dominated by maize.
Since 2012, CIMMYT has been working with the Ethiopian Institute of Agricultural Research (EIAR), the Ministry of Agriculture and other strategic partners like the Ethiopian Public Health Institute (EPHI), Sasakawa Global 2000 (SG2000) and Farm Radio International, to improve food and nutritional security in Ethiopian farming communities through the promotion and expansion of QPM under the Nutritious Maize for Ethiopia (NuME) project. This project built on the achievements of a previous project called Quality Protein Maize Development (QPMD). Both projects were financed by the government of Canada.
Workshop participants discuss the challenges of promoting QPM. (Photo: Simret Yasabu/CIMMYT)
Ethiopians are willing to pay for QPM
During the workshop, CIMMYT senior scientist and NuME project leader Adefris Teklewold talked about the favorable conditions that had contributed to the project’s success and which are also grounds for sustainability: government policies and strategies, technical knowledge and technology, and the productive collaboration among partners.
The NuME project operated in 36 woredas, or districts, of the Amhara, Oromia, SNNP and Tigray regions. More than 68% of the target population is now aware of the nutritional benefits of QPM, boosting the demand for the nutritious maize.
Four QPM varieties have been released since the beginning of the project and at least two promising varieties are in the pipeline. Figures show an adoption rate of 11% in the project’s target areas. Today, the main issue to reach out more people is shortage of seed.
The project team trained people in food preparation and organized events to demonstrate the benefits of QPM. One fifth of the 1,788 QPM demonstrations were managed entirely by women. Through demonstrations and blind tastings, people could check that QPM maize did not affect the taste or functional properties of traditional foods like dabo bread or injera flatbread. For instance, they realized that injera using QPM also stayed moist and could be rolled easily. In addition, a recent study on school feeding revealed that dishes made from QPM received wider acceptance.
A woman in Jimma, Oromia region, participates in a blind tasting of QPM maize products. (Photo: Samuel Diro/CIMMYT)
Beyond the NuME project
Germame Garuma, Director General of Extension at the Ministry of Agriculture, said that “QPM is an important solution to help us improve the nutrition situation in the country.” The Ethiopian government now aims to ensure 10% of the total maize growing area is planted with QPM. Ethiopia has included QPM as a key intervention in national strategies and programs, such as the Agriculture Growth Program-II and the Seqota Declaration.
Garuma called on all government offices at various levels and NGOs working in the agriculture and nutrition sector to continue the promotion of QPM. Workshop participants drew a roadmap with four focus areas: overall coordination, dissemination, technology generation and seed production. With the leadership of the Ministry of Agriculture, more families will be able to improve their diet with QPM in the future.
Dagmo Nour, Project Manager at Global Affairs Canada, expressed interest in engaging further with CIMMYT and its partners to ensure the sustainability and scaling of QPM efforts by addressing critical issues with Ethiopian seed systems.
Workshop participants pose for a group photograph.
A blindfolded woman panelist performing a triangular test to differentiate dabbo samples made from different maize varieties. Photo: CIMMYT
In Ethiopia, 44 percent of children under the age of five are stunted, or experience impaired growth due to poor nutrition, and 29 percent are underweight, according to the United States Agency for International Development. Quality protein maize (QPM) – a biofortified crop that increases lysine and tryptophan, two amino acids necessary for protein synthesis in humans – helps combat stunting and boosts nutrition in children who survive on a maize-dominated diet.
As maize is Ethiopia’s most consumed cereal, QPM could be especially beneficial to rural communities in the country, which consume more maize and suffer even higher rates of malnutrition than urban areas.
Until recently, farmers have been hesitant to adopt QPM over traditional varieties because the up-front cost is higher, and they have doubted the marketability due to the novelty of the variety. There is strong competition in productivity between QPM and conventional maize varieties and farmers tend to only plant newest or the best yielding varieties, where they feel sure they will get the highest return for their investment.
A study in Ethiopia found that farmers are willing to pay almost 50 percent more for quality protein maize (QPM) over conventionally grown maize, due to rising consumer preference for QPM varieties.
The major objective of the study was to know whether farmers as consumers have a preference for the QPM and if that would translate to a willingness to pay more for its attributes. As QPM is still a widely unknown variety, many farmers in the study had preconceived notions that it would be sour, would not taste good in traditional foods, or would be visually unappealing.
The study, conducted at CIMMYT as part of a MSc thesis, found that traditional food products made from QPM were correctly identified by most consumers, and were actually preferred over foods made from conventional maize. Farmers repeatedly expressed their preference for dabo, a local type of bread, made from QPM for its aroma, taste and texture. Mothers and children also consistently preferred genfo, a stiff maize-based porridge, made from QPM.
A slice of traditional bread called dabbo made from yellow QPM served for sensory evaluation. Photo: CIMMYT
Although traditional foods made from white grain/flour are usually preferred in Ethiopia, yellow QPM received higher preference than the white, signifying the trait responsible to its yellowness seems to contribute to its taste and functional property.
Based only on this taste difference, farmers were willing to pay as much as 48 percent more for QPM in some communities. On average, farmers were willing to pay 37 percent more for yellow QPM, but only five percent more for white QPM, due to the variability of sensory qualities between the white and yellow QPM varieties.
When given information about the increased nutritional benefit of QPM, farmer willingness to pay more for white QPM shot up to be roughly on par with yellow QPM, and reduced the amount that farmers said they would be willing to pay for conventional maize.
This suggests that the taste preference between white and yellow QPM is small and that education is a particularly powerful tool to increase its uptake among farmers.
Based on this study, QPM has an advantage in Ethiopia’s maize market not only because of its nutritional benefits but also aroma, taste, and texture, which is significant for women who are responsible for household diet.
QPM requires a special value chain that considers its nutritional advantage and taste, and strong extension communication is vital for the adoption of QPM as nutritional information reinforces the market share, specifically for white QPM. Extension agents could use the reported sensory preference for yellow QPM to begin large-market dissemination of QPM, alongside information about its nutritional advantages.
Consumer willingness to pay more for QPM grain should encourage maize farmers, seed suppliers and other stakeholders to invest in the variety. Market acceptability of QPM means more profits for stakeholders, facilitating adoption, and in this case, contributing to the fight against malnutrition.
Over two billion people across the world suffer from hidden hunger, the consumption of a sufficient number of calories, but still lacking essential nutrients such as vitamin A, iron or zinc. This can cause severe damage to health, blindness, or even death.
At the 4th annual Latin American Cereals Conference (LACC) in Mexico City from 11 to 14 March, presenters discussed global malnutrition and how biofortification of staple crops can be used to improve nutrition for farming families and consumers.
Wolfgang Pfeiffer of HarvestPlus presents on malnutrition and stunting. Photo: Jennifer Johnson/CIMMYT.
“A stunted child will never live up to its full potential,” said Wolfgang Pfeiffer, director of research and development at HarvestPlus, as he showed a slide comparing the brain of a healthy infant versus a stunted one.
Hidden hunger and stunting, or impaired development, are typically associated with poverty and diets high in staple crops such as rice or maize. Biofortification of essential nutrients into these staple crops has the potential to reduce malnutrition and micronutrient deficiencies around the world.
“Maize is a staple crop for over 900 million poor consumers, including 120-140 million poor families. Around 73% of farmland dedicated to maize production worldwide is located in the developing world,” said B.M. Prasanna, director of the CGIAR Research Program on Maize (MAIZE) at LACC.
The important role of maize in global diets and the rich genetic diversity of the crop has allowed for important breakthroughs in biofortifcation. The International Maize and Wheat Improvement Center (CIMMYT) has over 40 years of experience in maize breeding for biofortification, beginning with quality protein maize (QPM), which has enhanced levels of lysine and tryptophan, essential amino acids, which can help reduce malnutrition in children.
B.M. Prasanna discusses the history of maize biofortification at the LACC conference. Photo: Mike Listman/CIMMYT.
“Over 50 QPM varieties have been adopted in Latin America and the Caribbean and sub-Saharan Africa, and three new QPM hybrids were released in India in 2017 using marker assisted breeding,” said Prasanna.
In more recent years, CIMMYT has worked with MAIZE and HarvestPlus to develop provitamin A maize to reduce vitamin A deficiency, the leading cause of preventable blindness in children, affecting 5.2 million preschool-age children globally, according to the World Health Organization. This partnership launched their first zinc-enriched maize varieties in Honduras in 2017 and Colombia in 2018, with releases of new varieties planned in Guatemala and Nicaragua later this year. Zinc deficiency can lead to impaired growth and development, respiratory infections, diarrheal disease and a general weakening of the immune system.
“There is a huge deficiency of vitamin A, iron and zinc around the world,” said Natalia Palacios, maize nutritional quality specialist at CIMMYT. “The beauty of maize is its huge genetic diversity that has allowed us to develop these biofortified varieties using conventional breeding methods. The best way to take advantage of maize nutritional benefits is through biofortification, processing and functional food,” she said.
Natalia Palacios discusses the development of biofortified varieties such as provitamin A and zinc-enriched maize. Photo: Mike Listman/CIMMYT.
The effects of these varieties are already beginning to show. Recent studies have shown that vitamin A maize improves vitamin A status and night vision of 4-8 year old rural children in Zambia.
“Biofortified crops are in testing in over 60 countries, 7.5 million households are growing biofortified crops, and over 35 million household members are consuming them,” said Pfeiffer. “It is critical to involve farmers in the development of biofortified crop varieties before they are released, through participatory variety selection.”
Overall, the conference presenters agreed that ending hidden hunger will require cooperation and partnerships from multiple sectors and disciplines. “Partnerships with seed companies are crucial for biofortified maize to make an impact. This is not just about technological advances and developing new products, this is about enabling policies, stimulating demand, and increasing awareness about the benefits of these varieties,” said Prasanna.
This story is one of a series of features written during CIMMYT’s 50th anniversary year to highlight significant advancements in maize and wheat research between 1966 and 2016.
EL BATAN, Mexico (CIMMYT) – Maize and wheat biofortification can help reduce malnutrition in regions where nutritional options are unavailable, limited or unaffordable, but must be combined with education to be most effective, particularly as climate change jeopardizes food security, according to researchers at the International Maize and Wheat Improvement Center (CIMMYT).
Climate change could kill more than half a million adults in 2050 due to changes in diets and bodyweight from reduced crop productivity, a new report from the University of Oxford states. Projected improvement in food availability for a growing population could be cut by about a third, leading to average per-person reductions in food availability of 3.2 percent, reductions in fruit and vegetable intake of 4 percent and red meat consumption of .07 percent, according to the report.
Over the past 50 years since CIMMYT was founded in 1966, various research activities have been undertaken to boost protein quality and micronutrient levels in maize and wheat to help improve nutrition in poor communities, which the Oxford report estimates will be hardest hit by climate change. As one measure of CIMMYT’s success, scientists Evangelina Villegas and Surinder Vasal were recognized with the prestigious World Food Prize in 2000 for their work developing quality protein maize (QPM).
“We’ve got a lot of balls in the air to tackle the ongoing food security crisis and anticipate future needs as the population grows and the climate changes unpredictably,” said Natalia Palacios, head of maize quality, adding that a key component of current research is the strategic use of genetic resources held in the CIMMYT gene bank.
“CIMMYT’s contribution to boosting the nutritional value of maize and wheat is hugely significant for people who have access to these grains, but very little dietary diversity otherwise. Undernourishment is epidemic in parts of the world and it’s vital that we tackle the problem by biofortifying crops and including nutrition in sustainable intensification interventions.”
Undernourishment affects some 795 million people worldwide – meaning that more than one out of every nine people do not get enough food to lead a healthy, active lifestyle, according to the U.N. Food and Agriculture Organization (FAO). By 2050, reduced fruit and vegetable intake could cause twice as many deaths as under-nutrition, according to the Oxford report, which was produced by the university’s Future of Food Programme.
As staple foods, maize and wheat provide vital nutrients and health benefits, making up close to one-quarter of the world’s daily energy intake, and contributing 27 percent of the total calories in the diets of people living in developing countries, according to FAO.
“Nutrition is very complex and in addition to deploying scientific methods such as biofortification to develop nutritious crops, we try and serve an educational role, helping people understand how best to prepare certain foods to gain the most value,” Palacios said. “Sometimes communities have access to nutritious food but they don’t know how to prepare it without killing the nutrients.”
The value of biofortified crops is high in rural areas where people have vegetables for a few months, but must rely solely on maize for the rest of the year, she added, explaining that fortified flour and food may be more easily accessed in urban areas where there are more dietary options.
Some of the thousands of samples that make up the maize collection in the Wellhausen-Anderson Plant Genetic Resources Center at CIMMYT’s global headquarters in Texcoco, Mexico. (Photo: Xochiquetzal Fonseca/CIMMYT)
PROMOTING PROTEIN QUALITY
Conventional maize varieties cannot provide an adequate balance of amino acids for people with diets dominated by the grain and with no adequate alternative source of protein. Since the breakthrough findings of Villegas and Vasal, in some areas scientists now develop QPM, which offers an inexpensive alternative for smallholder farmers.
CIMMYT scientists also develop QPM and other nutritious conventionally bred maize varieties for the Nutritious Maize for Ethiopia (NuME) project funded by the government of Canada. NuME, which also helps farmers improve agricultural techniques by encouraging the deployment of improved agronomic practices, builds on a former seven-year collaborative QPM effort with partners in Ethiopia, Kenya, Tanzania and Uganda.
In Ethiopia, where average life expectancy is 56 years of age, the food security situation is critical due in part to drought caused by a recent El Nino climate system, according to the U.N. World Food Programme. More than 8 million people out of a population of 90 million people are in need of food assistance. Almost 30 percent of the population lives below the national poverty line, 40 percent of children under the age of 5 are stunted, 9 percent are acutely malnourished and 25 percent are underweight, according to the 2014 Ethiopia Mini Demographic and Health Survey. The NuMe project is helping to shore up sustainable food supplies and boost nutrition in the country, where the vast majority of people live in rural areas and are engaged in rain-fed subsistence agriculture.
INCREASING MICRONUTRIENTS
CIMMYT maize and wheat scientists tackle micronutrient deficiency, or “hidden hunger,” through the interdisciplinary, collaborative program HarvestPlus, which was launched in 2003 and is now part of the Agriculture for Nutrition and Health program managed by the CGIAR consortium of agricultural researchers.
Some 2 billion people around the world suffer from micronutrient deficiency, according to the World Health Organization (WHO). Micronutrient deficiency occurs when food does not provide enough vitamins and minerals. South Asia and sub-Saharan Africa are most affected by hidden hunger, which is characterized by iron-deficiency anemia, vitamin A and zinc deficiency.
Work at CIMMYT to combat micronutrient deficiency is aligned with the U.N. Sustainable Development Goals (SDGs) — in particular Goal 2, which aims to end all forms of malnutrition by 2030. The SDG also aims to meet internationally agreed targets on stunting and wasting in children under 5 years of age, and to address the nutritional needs of adolescent girls, older people, pregnant and lactating women by 2025.
WHOLESOME WHEAT
The wheat component of the HarvestPlus program involves developing and distributing wheat varieties with high zinc levels by introducing genetic diversity from wild species and landraces into adapted wheat.
Zinc deficiency affects about one-third of the world’s population, causing lower respiratory tract infections, malaria, diarrheal disease, hypogonadism, impaired immune function, skin disorders, cognitive dysfunction, and anorexia, according to the WHO, which attributes about 800,000 deaths worldwide each year to zinc deficiency. Additionally, worldwide, approximately 165 million children under five years of age are stunted due to zinc deficiency.
A project to develop superior wheat lines combining higher yield and high zinc concentrations in collaboration with national agriculture program partners in South Asia has led to new biofortified varieties 20 to 40 percent superior in grain zinc concentration.
“We’re playing a vital role in this area,” said CIMMYT wheat breeder Velu Govindan. “Our research has led to new varieties agronomically equal to, or superior to, other popular wheat cultivars with grain yield potential at par or — in some cases – even superior to popular wheat varieties adopted by smallholder farmers in South Asia where we’ve been focused.”
Scientists are studying the potential impact of climate-change related warmer temperatures and erratic rainfall on the nutritional value of wheat. An evaluation of the effect of water and heat stress with a particular focus on grain protein content, zinc and iron concentrations revealed that protein and zinc concentrations increased in water and heat-stressed environments, while zinc and iron yield was higher in non-stressed conditions.
“The results of our study suggest that genetic gains in yield potential of modern wheat varieties have tended to reduce grain zinc levels,” Govindan said. “In some instances, environmental variability might influence the extent to which this effect manifests itself, a key finding as we work toward finding solutions to the potential impact of climate change on food and nutrition security.”
Additionally, a recent HarvestPlus study revealed that modern genomic tools such as genomic selection hold great potential for biofortification breeding to enhance zinc concentrations in wheat.
IMPROVING MAIZE
Scientists working with HarvestPlus have developed vitamin A-enriched “orange” maize. Orange maize is conventionally bred to provide higher levels of pro-vitamin A carotenoids, a natural plant pigment found in such orange foods as mangoes, carrots, pumpkins, sweet potatoes, dark leafy greens and meat, converted into vitamin A by the body.
Maize breeders, who are currently working on developing varieties with 50 percent more pro-vitamin A than the first commercialized varieties released, identified germplasm with the highest amounts of carotenoids to develop the varieties. In Zambia, Zimbawe and Malawi, 12 varieties, which are agronomically competititve and have about 8ppm provitamin A, have been released.
Provitamin A from maize is efficiently absorbed and converted into vitamin A in the body. Stores of Vitamin A in 5 to 7 year old children improved when they ate orange maize, according to HarvestPlus research. The study also shows preliminary data demonstrating that children who ate orange maize for six months experienced an improved capacity of the eye to adjust to dim light. The findings indicate an improvement in night vision, a function dependent on adequate levels of vitamin A in the body.
Researchers are also developing maize varieties high in zinc.
Efforts on this front have been a major focus in Latin America, especially in Nicaragua, Guatemala and Colombia. Scientists expect the first wave of high zinc hybrids and varieties will be released in 2017. Further efforts are starting in such countries as Zambia, Zimbabwe and Ethiopia. Results from the first nutrition studies in young rural Zambian children indicate that biofortified maize can meet zinc requirements and provide an effective dietary alternative to regular maize for the vulnerable population.
