Skip to main content

Tag: biotechnology

Genes from ancestral relatives of wheat could boost its disease resistance, scientists say

FOR IMMEDIATE RELEASE

El BatĂĄn, Texcoco (Mexico), August 3, 2018

As societies consider the advantages and risks of modern biotechnology, including genetic modification and gene editing, a commentary by scientists from the John Innes Centre (JIC) and the International Maize and Wheat Improvement Center (CIMMYT), published in Science magazine today, highlights the potential for deploying genes from ancestral relatives of wheat to strengthen its disease resistance.

Spontaneous natural crosses between wild ancestors created bread wheat some 10,000 years ago. Subsequent domestication and breeding by humans has made it one of the world’s foremost food crops. This process has also lessened the crop’s genetic diversity for stress and disease resistances found in its wild relatives.

It is thus rare to find resistance to a new disease race among currently grown wheat varieties. Wild relatives of wheat provide a larger, naturally-occurring treasure trove of resistance.

Conventional cross-breeding is being used to transfer beneficial traits, including disease resistance, from wild relatives into today’s wheat varieties, but such transfers carry along many undesirable genes that must be removed through painstaking selection in repeated generations of breeding lines — a process that takes many years.

Meanwhile, rapidly emerging and evolving races of wheat stem rust and stripe rust diseases, the crop’s deadliest scourges worldwide, are quickly overcoming the genetic resistance of many widely grown wheat cultivars. Other wheat diseases are spreading beyond their place of origin. For example, wheat blast, which is native to South America, unexpectedly devastated parts of the wheat crop in Bangladesh in 2016. It could now spread to other areas at risk in South Asia, where wheat covers 15 million hectares and nearly a billion inhabitants eat wheat.

The Science article notes that research thus far has missed the opportunity of using some of the tools of modern biotechnology to more effectively access diversity from wild relatives of wheat and provide it with a “multilayered” disease resistance that pathogens could not easily overcome. The process is no different from what conventional crossing or natural out-crossing could do, except that it is faster, the chance of success is much higher and it may be the only affordable approach to provide durable resistance.

Fact-based decisions are needed by the international community and individual countries regarding the potential use of modern biotechnology to ensure food security. That use must reflect concerns of human and animal health and environmental safety, as well as respect to national sovereignty, regulations and procedures.

By the same token, decisions must take into account the interests of the people who are most affected when new diseases devastate livelihoods and drive up consumer prices: smallholder farmers and consumers in the developing world.

Click here to read CIMMYT’s position statement on genetic modification.

Click here to read the full article on Science magazine.

FOR MORE INFORMATION, CONTACT THE MEDIA TEAM:

Rodrigo Ordóñez, Communications Manager, CIMMYT. r.ordonez@cgiar.org, +52 (55) 5804 2004 ext. 1167.

Ricardo Curiel, Communications Officer, CIMMYT. r.curiel@cgiar.org, +52 (55) 5804 2004 ext. 1144.

 

 

Zhonghu He

Zhonghu He serves as a Distinguished Scientist and Country Representative in China for CIMMYT and a Research Professor at the Chinese Academy of Agricultural Science. Research areas include quality improvement of Chinese products and disease resistance, molecular marker development and application, and cultivar development.

Major contributions include the development and validation of 50 functional markers, the release of 36 improved cultivars, author/coauthor of more than 400 papers in refereed journals including 180 publications in international journals, and training more than 80 postgraduates and visiting scientists.

Received the First-Class Award and Prestigious Award in Science and Technology Progress from State Council in 2008 and 2015, selected as Fellow of Crop Science Society of America in 2009 and Fellow of American Society of Agronomy in 2013, the Guanghua Award from Chinese Academy of Engineering in 2010, the China Agriculture Elite Award in 2012, and the National Labor Medal in 2020.

B.M. Prasanna

B.M. Prasanna is a Distinguished Scientist and Regional Director for Asia at CIMMYT.

Since 2010, Prasanna, as the Global Maize Program Director, has provided technical oversight for a wide range of multi-institutional projects focused on the development and deployment of elite, stress-resilient, and nutritionally enriched maize varieties across the tropics of sub-Saharan Africa, Asia, and Latin America. He has also spearheaded the application of innovative tools and technologies aimed at enhancing genetic gains and improving breeding efficiency.

Prasanna led the CGIAR Research Program MAIZE from 2015 till 2021, an alliance of over 300 research and development institutions globally. He has been at the forefront in tackling the challenges of maize lethal necrosis (MLN) disease in eastern Africa (since 2011), and the Fall Armyworm in Africa and Asia (since 2016 and 2018, respectively).

Together with an array of partners globally, Prasanna and the wider CGIAR team have formulated the OneCGIAR Plant Health Initiative in 2021. Prasanna is currently also serving as the Leader of the Plant Health Initiative, involving 10 CGIAR centers and over 80 national and international partners.

Recipient of several awards and recognitions, Prasanna has published over 200 research articles in various international journals of repute, and has a Scopus h-index of 46, and a Google Scholar h-index of 61.

Karim Ammar

Karim Ammar is a principal scientist and head of durum wheat and triticale breeding at CIMMYT. He conducts a globally-focused, extensive and proactive breeding effort to produce improved germplasm of high value and relevance to collaborators worldwide.

Durum wheat profitability requires sustained gains in genetic yield potential, adaptation to a wide range of water availability and temperature conditions, durable genetic protection against major pathogens and quality attributes that allow harvests to be marketed readily.

In addition, Ammar is involved in research that widens the genetic bases of resistance to rusts and septoria diseases, develops molecular tools to select more durable resistance, enhances breeding capacity for effective drought and heat tolerance, and to diversify quality characteristics of durum wheat grain. He also focuses on improving and promoting triticale as an input saving, low production cost feed and forage option in livestock-cereals operations.

Kanwarpal S. Dhugga

Kanwarpal Dhugga is a principal scientist specializing in biotechnology, specifically editing genes for disease resistance in maize and wheat in collaboration with DowDuPont, a company that has pioneered this technology in plants.

CRISPR-Cas9 has revolutionized the area of gene editing by altering the function of a gene in its native form in the target organism. In collaboration with DowDuPont, Dhugga and colleagues have applied this technology and fine-mapped a strong quantitative trait locus for maize lethal necrosis (MLN) resistance to a narrow interval, identifying a candidate gene for further testing. MLN has severely reduced maize grain yield in eastern Africa since 2011.

DowDuPont will edit the candidate gene directly in MLN-susceptible CIMMYT lines to validate its function and potentially deploy resistant hybrids. In wheat, Dhugga is focusing on creating the alleles for Lr67, which confers adult plant resistance against multiple rusts, directly in elite lines Reedling and Kachu.

Kevin Pixley

Kevin Pixley is the Dryland Crops Program Director (DCP) and Wheat Program Director a.i. (GWP)

Pixley was formerly the Genetic Resources Program (GRP) director where he helped formulate, facilitate, and oversee inter-disciplinary strategies to enhance the relevance and impacts of wheat and maize research to improve livelihoods, especially for resource-poor farmers.

Pixley and his research team use genomics, phenomics and informatics to characterize and enhance the conservation and use of wheat and maize biodiversity through CIMMYT’s Seeds of Discovery initiative, where they explore the use of crop biodiversity to address novel opportunities, including enhanced sustainability of farming systems, improved nutritional or health outcomes or value-addition for farmers. They also look for opportunities to apply novel technologies to address needs of resource-poor farmers.

His current research includes:

1) The genomic characterization of maize and wheat germplasm bank diversity and enhancing the use of diversity in breeding

2) The use of novel breeding tools, especially gene editing, to complement traditional breeding techniques

3) The development of tools and approaches to enhance the use of genomics in teaching the use of biodiversity in plant breeding

4) The legal frameworks governing and opportunities promoting fair access and sharing of benefits from genetic resources

5) The role of provitamin A carotenoids (and other anti-oxidants) in maize grain towards reducing mycotoxin contamination of grain

6) Science and society, including how to ensure equitable opportunity for all to access the potential benefits of science