MARPLE team members Dave Hodson and Diane Saunders (second and third from left) stand for a photograph after receiving the International Impact award. With them is Malcolm Skingle, director of Academic Liaison at GlaxoSmithKline (first from left) and Melanie Welham, executive chair of BBSRC. (Photo: BBSRC)
The research team behind the MARPLE (Mobile And Real-time PLant disEase) diagnostic kit won the International Impact category of the Innovator of the Year 2019 Awards, sponsored by the United Kingdom’s Biotechnology and Biological Sciences Research Council (BBSRC).
The team — Diane Saunders of the John Innes Centre (JIC), Dave Hodson of the International Maize and Wheat Improvement Center (CIMMYT) and Tadessa Daba of the Ethiopian Institute for Agricultural Research (EIAR) — was presented with the award at an event at the London Science Museum on May 15, 2019. In the audience were leading figures from the worlds of investment, industry, government, charity and academia, including the U.K.’s Minister of State for Universities, Science, Research and Innovation, Chris Skidmore.
The BBSRC Innovator of the Year awards, now in their 11th year, recognize and support individuals or teams who have taken discoveries in bioscience and translated them to deliver impact. Reflecting the breadth of research that BBSRC supports, they are awarded in four categories of impact: commercial, societal, international and early career. Daba, Hodson and Saunders were among a select group of 12 finalists competing for the four prestigious awards. In addition to international recognition, they received £10,000 (about $13,000).
“I am delighted that this work has been recognized,” Hodson said. “Wheat rusts are a global threat to agriculture and to the livelihoods of farmers in developing countries such as Ethiopia. MARPLE diagnostics puts state-of-the-art, rapid diagnostic results in the hands of those best placed to respond: researchers on the ground, local government and farmers.”
On-the-ground diagnostics
The MARPLE diagnostic kit is the first operational system in the world using nanopore sequence technology for rapid diagnostics and surveillance of complex fungal pathogens in the field.
In its initial work in Ethiopia, the suitcase-sized field test kit has positioned the country — one of the region’s top wheat producers — as a world leader in pathogen diagnostics and forecasting. Generating results within 48 hours of field sampling, the kit represents a revolution in plant disease diagnostics. Its use will have far-reaching implications for how plant health threats are identified and tracked into the future.
MARPLE is designed to run at a field site without constant electricity and with the varying temperatures of the field.
“This means we can truly take the lab to the field,” explained Saunders. “Perhaps more importantly though, it means that smaller, less-resourced labs can drive their own research without having to rely on a handful of large, well-resourced labs and sophisticated expertise in different countries.”
In a recent interview with JIC, EIAR Director Tadessa Daba said, “we want to see this project being used on the ground, to show farmers and the nation this technology works.”
The MARPLE team uses the diagnostic kit in Ethiopia. (Photo: JIC)
Development of the MARPLE diagnostic kit was funded by the Biotechnology and Biological Sciences Research Council (BBSRC) and the CGIAR Platform for Big Data in Agriculture’s Inspire Challenge. Continued support is also provided by the BBSRC’s Excellence with Impact Award to the John Innes Centre and the Delivering Genetic Gain in Wheat project, led by Cornell University and funded by the UK’s Department for International Development (DFID) and the Bill & Melinda Gates Foundation.
In an attempt to curb the spread of this disease, policymakers in the region are considering a “wheat holiday” policy: banning wheat cultivation for a few years in targeted areas. Since wheat blast’s Magnaporthe oryzae pathotype triticum (MoT) fungus can survive on seeds for up to 22 months, the idea is to replace wheat with other crops, temporarily, to cause the spores to die. In India, which shares a border of more than 4,000 km with Bangladesh, the West Bengal state government has already instituted a two-year ban on wheat cultivation in two districts, as well as all border areas. In Bangladesh, the government is implementing the policy indirectly by discouraging wheat cultivation in the severely blast affected districts.
CIMMYT researchers recently published in two ex-ante studies to identify economically feasible alternative crops in Bangladesh and the bordering Indian state of West Bengal.
Alternative crops
The first step to ensuring that a ban does not threaten the food security and livelihoods of smallholder farmers, the authors assert, is to supply farmers with economically feasible alternative crops.
In Bangladesh, the authors examined the economic feasibility of seven crops as an alternative to wheat, first in the entire country, then in 42 districts vulnerable to blast, and finally in ten districts affected by wheat blast. Considering the cost of production and revenue per hectare, the study ruled out boro rice, chickpeas and potatoes as feasible alternatives to wheat due to their negative net return. In contrast, they found that cultivation of maize, lentils, onions, and garlic could be profitable.
The study in India looked at ten crops grown under similar conditions as wheat in the state of West Bengal, examining the economic viability of each. The authors conclude that growing maize, lentils, legumes such as chickpeas and urad bean, rapeseed, mustard and potatoes in place of wheat appears to be profitable, although they warn that more rigorous research and data are needed to confirm and support this transition.
Selecting alternative crops is no easy task. Crops offered to farmers to replace wheat must be appropriate for the agroecological zone and should not require additional investments for irrigation, inputs or storage facilities. Also, the extra production of labor-intensive and export-oriented crops, such as maize in India and potatoes in Bangladesh, may add costs or require new markets for export.
There is also the added worry that the MoT fungus could survive on one of these alternative crops, thus completely negating any benefit of the “wheat holiday.” The authors point out that the fungus has been reported to survive on maize.
A short-term solution?
The grain in this blast-blighted wheat head has been turned to chaff. (Photo: CKnight/DGGW/ Cornell University)
In both studies, the authors discourage a “wheat holiday” policy as a holistic solution. However, they leave room for governments to pursue it on an interim and short-term basis.
In the case of Bangladesh, CIMMYT agricultural economist and lead author Khondoker Mottaleb asserts that a “wheat holiday” would increase the country’s reliance on imports, especially in the face of rapidly increasing wheat demand and urbanization. A policy that results in complete dependence on wheat imports, he and his co-authors point out, may not be politically attractive or feasible. Also, the policy would be logistically challenging to implement. Finally, since the disease can potentially survive on other host plants, such as weeds and maize, it may not even work in the long run.
In the interim, the government of Bangladesh may still need to rely on the “wheat holiday” policy in the severely blast-affected districts. In these areas, they should encourage farmers to cultivate lentils, onions and garlic. In addition, in the short term, the government should make generic fungicides widely available at affordable prices and provide an early warning system as well as adequate information to help farmers effectively combat the disease and minimize its consequences.
In the case of West Bengal, India, similar implications apply, although the authors conclude that the “wheat holiday” policy could only work if Bangladesh has the same policy in its blast-affected border districts, which would involve potentially difficult and costly inter-country collaboration, coordination and logistics.
Actions for long-term success
The CIMMYT researchers urge the governments of India and Bangladesh, their counterparts in the region and international stakeholders to pursue long-term solutions, including developing a convenient diagnostic tool for wheat blast surveillance and a platform for open data and science to combat the fungus.
A promising development is the blast-resistant (and zinc-enriched) wheat variety BARI Gom 33 which the Bangladesh Agricultural Research Institute (BARI) released in 2017 with support from CIMMYT. However, it will take at least three to five years before it will be available to farmers throughout Bangladesh. The authors urged international donor agencies to speed up the multiplication process of this variety.
CIMMYT scientists in both studies close with an urgent plea for international financial and technical support for collaborative research on disease epidemiology and forecasting, and the development and dissemination of new wheat blast-tolerant and resistant varieties and complementary management practices — crucial steps to ensuring food security for more than a billion people in South Asia.
Wheat blast impacts
First officially reported in Brazil in 1985, where it eventually spread to 3 million hectares in South America and became the primary reason for limited wheat production in the region, wheat blast moved to Bangladesh in 2016. There it affected nearly 15,000 hectares of land in eight districts, reducing yield by as much as 51 percent in the affected fields.
Blast is devilish: directly striking the wheat ear, it can shrivel and deform the grain in less than a week from the first symptoms, leaving farmers no time to act. There are no widely available resistant varieties, and fungicides are expensive and provide only a partial defense. The disease, caused by the fungus Magnaporthe oryzae pathotype triticum (MoT), can spread through infected seeds as well as by spores that can travel long distances in the air.
South Asia has a long tradition of wheat consumption, especially in northwest India and Pakistan, and demand has been increasing rapidly across South Asia. It is the second major staple in Bangladesh and India and the principal staple food in Pakistan. Research indicates 17 percent of wheat area in Bangladesh, India, and Pakistan — representing nearly 7 million hectares – is vulnerable to the disease, threatening the food security of more than a billion people.
Wheat blast is a fast-acting and devastating fungal disease that threatens food safety and security in the Americas and South Asia.
First officially identified in Brazil in 1984, the disease is widespread in South American wheat fields, affecting as much as 3 million hectares in the early 1990s.
In 2016, it crossed the Atlantic Ocean, and Bangladesh suffered a severe outbreak. Bangladesh released a blast-resistant wheat variety — developed with breeding lines from the International Maize and Wheat Improvement Center (CIMMYT) — in 2017, but the country and region remain extremely vulnerable.
The continued spread of blast in South Asia — where more than 100 million tons of wheat are consumed each year — could be devastating.
Researchers with the CIMMYT-led and USAID-supported Cereal Systems Initiative for South Asia (CSISA) and Climate Services for Resilient Development (CSRD) projects partner with national researchers and meteorological agencies on ways to work towards solutions to mitigate the threat of wheat blast and increase the resilience of smallholder farmers in the region. These include agronomic methods and early warning systems so farmers can prepare for and reduce the impact of wheat blast.
This series of infographics shows how wheat blast spreads, its potential effect on wheat production in South Asia and ways farmers can manage it.
This work is funded by the U.S. Agency for International Development (USAID) and the Bill & Melinda Gates Foundation. CSISA partners include CIMMYT, the International Food Policy Research Institute (IFPRI) and the International Rice Research Institute (IRRI).
